ChemicalBook > CAS DataBase List > 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

Product Name: 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
CAS No.: 1256349-48-0
Chemical Name: 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-
Synonyms: Chiauranib;ibcasertib;Chiauranib (CS2164);Chiauranib/1256349-48-0;Chiauranib, 10 mM in DMSO;N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide;N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms
CBNumber: CB98119659
Molecular Formula: C27H21N3O3
Formula Weight: 435.47
MOL File: 1256349-48-0.mol

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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Property

Boiling point:: 604.6±50.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 62.5 mg/mL (143.52 mM; Need ultrasonic)
pka: 12.77±0.70(Predicted)
form: Solid
color: White to light brown

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Hazard and Precautionary Statements (GHS)

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1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Chemical Properties,Usage,Production

Uses

Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects[1].

in vivo

Chiauranib (CS2164; 0.5-40 mg/kg; oral administration; once daily; for 33 days or 43 days) treatment induces remarkable regression or complete inhibition of tumor growth at well-tolerated oral doses in several human tumor xenograft models. Chiauranib exhibits broad and potent in vivo anti-tumor activities^[1].

Animal Model:	Female BALB/c athymic (nu⁺/nu⁺) mice (6-week old) bearing HCT-8, SMMC-7721, MGC‐803 or A549 cells^[1]
Dosage:	2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration:	Oral administration; once daily; for 33 days or 43 days
Result:	Induced remarkable regression or complete inhibition of tumor growth in several human tumor xenograft models.

IC 50

Flt-1: 8 nM (IC₅₀); KDR: 7 nM (IC₅₀); Flt-4: 9 nM (IC₅₀); PDGFRα: 1 nM (IC₅₀); c-Kit: 4 nM (IC₅₀); Aurora B: 9 nM (IC₅₀); PDGFRβ: 93 nM (IC₅₀); CSF-1R: 7 nM (IC₅₀)

References

[1] You Zhou, et al. CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency. Cancer Sci. 2017 Mar;108(3):469-477. DOI:10.1111/cas.13141

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1256349-48-0, 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-Related Search:

1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-

N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide

Chiauranib

Chiauranib (CS2164)

ibcasertib

CSF-1R,VEGFR2,CSF1R,Vascular endothelial growth factor receptor,VEGFR3,anti-angiogenesis,CD117,Aurora Kinase,c-Kit,CS-2164,CSF-1 receptor,Chiauranib,colony stimulating factor 1 receptor,PDGFRα,PDGFR,Aurora-B,anticancer,inhibit,SCFR,Inhibitor,VEGFR,Platelet-derived growth factor receptor,CS 2164,VEGFR1,c-Fms

N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide

Chiauranib, 10 mM in DMSO

Chiauranib/1256349-48-0

1256349-48-0