1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- CAS No.
- 1424635-83-5
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- Synonyms
- TRULI;Lats-IN-1;TRULI/Lats-IN-1;Lats-IN-1(TRULI );Lats-IN-1, 10 mM in DMSO;inhibit,LatsIN1,YAP,Yes-associated protein,Lats IN 1,Inhibitor;N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;(Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- CBNumber
- CB98123852
- Molecular Formula
- C18H14N4OS
- Formula Weight
- 334.39
- MOL File
- 1424635-83-5.mol
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Property
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 83.33 mg/mL (249.20 mM)
- form
- A solid
- pka
- 12.30±0.40(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1280924
- Product name
- N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 10mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- A1280924
- Product name
- N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 25mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- CSN26140
- Product name
- TRULI
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- A1280924
- Product name
- N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 50mg
- Price
- $277
- Updated
- 2021/12/16
- Product number
- A1280924
- Product name
- N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $445
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Chemical Properties,Usage,Production
Uses
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].
Biological Activity
TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) th at induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
References
[1] Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.