Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-

Product Name: Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
CAS No.: 757192-67-9
Chemical Name: Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
Synonyms: EN106;2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide;Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
CBNumber: CB98291959
Molecular Formula: C13H13ClN2O3
Formula Weight: 280.71
MOL File: 757192-67-9.mol

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Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Property

Boiling point:: 489.1±45.0 °C(Predicted)
Density: 1.351±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (890.60 mM; Need ultrasonic)
pka: 0.42±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3516
Product name: EN106
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $63.27
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3516
Product name: EN106
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

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Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Chemical Properties,Usage,Production

Uses

EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1[1].

Biological Activity

EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B th at binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.

References

[1] Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. DOI:10.1021/jacs.1c03980

Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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757192-67-9, Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-Related Search:

Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-

EN106

2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide

757192-67-9