ChemicalBook > CAS DataBase List > L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- Product Name
- L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- CAS No.
- 2172819-72-4
- Chemical Name
- L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- Synonyms
- AHPC-C2-COOH;VH032-C1-COOH;(S,R,S)-CO-C2-acid;(S,R,S)-AHPC-C2-COOH;VH 032 anide-alky1C2-acid;VH 032 amide-alkylC2-acid;(S,R,S)-AHPC-amido-C2-acid;L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid;3-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}propanoic acid
- CBNumber
- CB98379600
- Molecular Formula
- C26H34N4O6S
- Formula Weight
- 530.64
- MOL File
- 2172819-72-4.mol
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L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Property
- Boiling point:
- 868.3±65.0 °C(Predicted)
- Density
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- methanol, ethyl acetate, DCM, THF, DMF, DMSO
- pka
- 4.70±0.10(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- Appearance
- beige powder
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N-Bromosuccinimide Price
Tocris
- Product number
- 7106
- Product name
- VH032amide-alkylC2-acid
- Purity
- ≥95%(HPLC)
- Packaging
- 25
- Price
- $245
- Updated
- 2021/12/16
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L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties,Usage,Production
Description
(S,R,S)-AHPC-amido-C2-acid is a VHL ligand with a 2 carbon alkyl linker and terminal acid for PROTAC compounds.
Uses
(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands[1].
storage
Store at -20°C
References
[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912
L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Raw materials
Preparation Products
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L-Prolinamide, N-(3-carboxy-1-oxopropyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers
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