MANZAMINE A

Product Name: MANZAMINE A
CAS No.: 104196-68-1
Chemical Name: MANZAMINE A
Synonyms: MANZAMINE A;Keramamine A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
CBNumber: CB9838727
Molecular Formula: C36H44N4O
Formula Weight: 548.76
MOL File: 104196-68-1.mol

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MANZAMINE A Property

Melting point:: ＞240(disassembly)
Boiling point:: 756.6±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml).
form: Off white to yellow solid.
pka: 13.58±0.40(Predicted)
color: Off-White to Pale Yellow
optical activity: +5020 (CHCl3)
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21444
Product name: Manzamine A
Purity: ≥98%
Packaging: 500μg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 21444
Product name: Manzamine A
Purity: ≥98%
Packaging: 1mg
Price: $232
Updated: 2024/03/01

TRC

Product number: M186003
Product name: ManzamineA
Packaging: 2.5mg
Price: $795
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546096
Product name: Manzamine A
Purity: >98%
Packaging: 5mg
Price: $1281.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546096
Product name: Manzamine A
Purity: >98%
Packaging: 1mg
Price: $365.5
Updated: 2021/12/16

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MANZAMINE A Chemical Properties,Usage,Production

Description

Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.

Uses

Manzamine A is a β-Carboline alkaloid with anti-inflammatory.

Definition

ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

in vivo

Manzamine A (50 and 100 mol/kg, p.o. or i.p.) inhibits the growth of the rodent malaria parasitePlasmodium berghei in infected mice^[6].
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) prolongs the survival of SW mice to 20 days^[7].

Animal Model:	Plasmodium berghei in infected mice^[6]
Dosage:	50 or 100 mol/kg
Administration:	Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:	Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice.

IC 50

Plasmodium; GSK-3β: 10.2 μM (IC₅₀); CDK5: 1.5 μM (IC₅₀); vacuolar ATPases; Malaria; HSV-1

storage

+4°C

References

[1] GEORGIOS KALLIFATIDIS. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.[J]. Marine Drugs, 2013, 11 9: 3500-3516. DOI:10.3390/md11093500
[2] KEISUKE EGUCHI . Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo[J]. Bioorganic & Medicinal Chemistry, 2013, 21 13: Pages 3831-3838. DOI:10.1016/j.bmc.2013.04.025
[3] BO ZHANG. Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. ingens (Thiele, 1899).[J]. Chemical & pharmaceutical bulletin, 2008, 56 6: 866-869. DOI:10.1248/cpb.56.866
[4] MARK HAMANN. Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease[J]. Journal of Natural Products , 2007, 70 9: 1397-1405. DOI:10.1021/np060092r

MANZAMINE A Preparation Products And Raw materials

Raw materials

Preparation Products

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MANZAMINE A Suppliers

China 46 Switzerland 2 United Kingdom 3 United States 8 Global 59

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-028-85142057 19983342022
Fax: 028-85142057
Email: 3005359975@qq.com
Country: China
ProdList: 1991
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

104196-68-1, MANZAMINE ARelated Search:

OUABAIN OCTAHYDRATE AR-A014418 SB216763 Ethacrynic acid 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE SB 415286 1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE CAFESTOL 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE (R)-TERT-LEUCINOL 3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-OL 4-PYRIDIN-2-YL-BUTYLAMINE MANZAMINE A N,N-DIBUTYL-2-ETHYLHEXYLAMINE manzamine F

MANZAMINE A

1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-

Keramamine A

104196-68-1

C36H44N4O