1-(2-METHYLPYRIDIN-4-YL)ETHANONE

Product Name: 1-(2-METHYLPYRIDIN-4-YL)ETHANONE
CAS No.: 2732-28-7
Chemical Name: 1-(2-METHYLPYRIDIN-4-YL)ETHANONE
Synonyms: 4-Acetyl-2-methylpyridine;1-(2-Methyl-4-pyridyl)ethanone;1-(2-METHYLPYRIDIN-4-YL)ETHANONE;1-(2-Methyl-4-pyridinyl)-Ethanone;Ketone, methyl 2-methyl-4-pyridyl;Ethanone,1-(2-Methyl-4-pyridinyl)-;1-(2-Methylpyridin-4-yl)ethan-1-one
CBNumber: CB9841594
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 2732-28-7.mol

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1-(2-METHYLPYRIDIN-4-YL)ETHANONE Property

Melting point:: 149 °C
Boiling point:: 130 °C(Press: 4 Torr)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 4.25±0.10(Predicted)
Appearance: Light yellow to light brown Solid-Liquid Mixture

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37
Safety Statements: 26-36/37
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M338008
Product name: 1-(2-Methylpyridin-4-yl)ethanone
Packaging: 500mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: W5046
Product name: 4-Acetyl-2-methylpyridine
Packaging: 5g
Price: $771
Updated: 2021/12/16

Matrix Scientific

Product number: 073065
Product name: 4-Acetyl-2-methylpyridine
Purity: 95+%
Packaging: 1g
Price: $1158
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0125371
Product name: 1-(2-METHYL-PYRIDIN-4-YL)-ETHANONE
Purity: 97.00%
Packaging: 250MG
Price: $1167.71
Updated: 2021/12/16

AK Scientific

Product number: W5046
Product name: 4-Acetyl-2-methylpyridine
Packaging: 25g
Price: $2451
Updated: 2021/12/16

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1-(2-METHYLPYRIDIN-4-YL)ETHANONE Chemical Properties,Usage,Production

Definition

ChEBI: 4-Acetyl-2-methylpyridine is an aromatic ketone.

Synthesis

1211580-90-3

917-54-4

2732-28-7

Step 3: Synthesis of 1-(2-methylpyridin-4-yl)ethanone (46d) To a stirred tetrahydrofuran (THF) solution (520 mL) of N-methoxy-N,2-dimethylisonicotinamide (46c) (26 g, 144.28 mmol) under nitrogen protection, methyl lithium (MeLi, 6.342 g, 288.562 mmol, 1M THF solution) was slowly added at -78 °C. The reaction mixture was gradually warmed to room temperature over a period of 1 h, followed by quenching the reaction with saturated ammonium chloride (NH4Cl) solution at 0 °C. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by column chromatography to afford 1-(2-methylpyridin-4-yl)ethanone (46d) (11 g, 56.4% yield) as a slightly red viscous liquid. 1H NMR (CDCl3) δ: 8.61-8.59 (d, 1H), 7.51-7.45 (d, 1H), 7.45-7.44 (m, 1H), 4.05-4.02 (s, 3H). MS (ES+): 136.1 (M + 1).

References

[1] Patent: WO2015/134998, 2015, A1. Location in patent: Page/Page column 840; 841
[2] Patent: WO2017/59178, 2017, A1. Location in patent: Page/Page column 151
[3] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 141; 142
[4] Patent: WO2013/19626, 2013, A1. Location in patent: Page/Page column 34; 35

1-(2-METHYLPYRIDIN-4-YL)ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-METHYLPYRIDIN-4-YL)ETHANONE Suppliers

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2732-28-7, 1-(2-METHYLPYRIDIN-4-YL)ETHANONERelated Search:

1-(2-Methylpyridin-3-yl)ethanone 1-(2-fluoro-3-nitrophenyl)ethanone 1-(3-BROMO-2-METHYLPYRIDIN-4-YL)ETHANONE 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-1-VINYL-PYRROLIDIN-2-ONE [2,2'-BIPYRIDIN]-4-YL-PHENYL-METHANONE AURORA KA-8155 1-(6-Methyl-2-phenyl-4-quinolinyl)-2-(4-piperidinyl)ethanone 4-Acetyl-2-cyanopyridine 1-(2-METHYLPYRIDIN-4-YL)ETHANONE 1-(3-AMINO-2-METHYLPYRIDIN-4-YL)ETHANONE 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-1-VINYL-AZEPAN-2-ONE bis[2,8-di(trifluoromethyl)quinolin-4-yl-2-pyridyl] ketone 3-(2-PHENYL-QUINOLINE-4-CARBONYL)-PIPERIDIN-2-ONE Ethanone, 1-(2,6-dimethyl-4-pyridinyl)- (9CI) bostrycoidin Cyclopropyl-(2-methyl-4-pyridinyl)-methanone

1-(2-METHYLPYRIDIN-4-YL)ETHANONE

4-Acetyl-2-methylpyridine

1-(2-Methylpyridin-4-yl)ethan-1-one

1-(2-Methyl-4-pyridinyl)-Ethanone

Ethanone,1-(2-Methyl-4-pyridinyl)-

Ketone, methyl 2-methyl-4-pyridyl

1-(2-Methyl-4-pyridyl)ethanone

2732-28-7

Heterocycle-Pyridine series