amisometradine
- Product Name
- amisometradine
- CAS No.
- 550-28-7
- Chemical Name
- amisometradine
- Synonyms
- Rolicton;amisometradine;Aminoisometradin;Aminoisometradine;6-Amino-3-methyl-1-(2-methylallyl)uracil;6-amino-3-methyl-1-(2-methylallyl)pyrimidine-2,4-quinone;6-amino-3-methyl-1-(2-methylprop-2-enyl)pyrimidine-2,4-dione;6-azanyl-3-methyl-1-(2-methylprop-2-enyl)pyrimidine-2,4-dione;6-Amino-3-methyl-1-(2-methyl-2-propenyl)pyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-1-(2-methyl-2-propen-1-yl)-
- CBNumber
- CB9920813
- Molecular Formula
- C9H13N3O2
- Formula Weight
- 195.22
- MOL File
- 550-28-7.mol
amisometradine Property
- Melting point:
- 175°
- Boiling point:
- 331.89°C (rough estimate)
- Density
- 1.1985 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.97±0.70(Predicted)
- color
- White to Pale Beige
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- A633600
- Product name
- Amisometradine
- Packaging
- 50mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- A633600
- Product name
- Amisometradine
- Packaging
- 100mg
- Price
- $640
- Updated
- 2021/12/16
- Product number
- API0010583
- Product name
- 6-AMINO-3-METHYL-1-(2-METHYLPROP-2-EN-1-YL)-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.27
- Updated
- 2021/12/16
amisometradine Chemical Properties,Usage,Production
Originator
Rolicton,Searle,US,1956
Uses
Amisometradine is an oral diuretic.
Definition
ChEBI: Amisometradine is a pyrimidone.
Manufacturing Process
Preparation of the ethyl analog is as follows (methyl isocyanate is used in
amisometradine manufacture).
To a cooled and stirred solution of 142 parts of methallylamine in 900 parts of
benzene, 156 parts of ethyl isocyanate are added dropwise. Upon
concentration in vacuum N-ethyl-N'-methallylurea is obtained.
260 parts of this urea derivative are dissolved in 500 parts of acetic anhydride
and treated with 157 parts of cyanoacetic acid at 60°C and heated at that
temperature for 2 hours. The solution is then concentrated in vacuum to a
syrup. 100 parts of water are added and the vacuum distillation is repeated.
The remaining syrup contains a mixture of N-cyanoacetyl-N-ethyl-N'-
methallylurea and a small quantity of N-cyanoacetyl-N-methallyl-N'-ethylurea.
This syrup is treated with sufficient 20% sodium hydroxide solution to raise
the pH to 10. A violent reaction occurs. The reaction mixture is diluted with 50
parts of water, stirred, cooled and filtered. The material collected on the filter
is recrystallized from 10% ethanol to yield a mixture of 1-methallyl-3-ethyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione and 1-ethyl-3-methallyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione melting at about 157-159°C.
Therapeutic Function
Diuretic
amisometradine Preparation Products And Raw materials
Raw materials
Preparation Products
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