4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride Chemical Properties

Melting point:

>240°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

100vol% at 20℃[vol%]

Stability:

Hygroscopic, Moisture Sensitive

4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride Usage And Synthesis

Uses

4-((4-Methylpiperazin-1-yl)methyl)benzoyl Chloride Dihydrochloride is an intermediate in the synthesis of Gleevec N-4-((4-Methylpiperazin-1-yl)methyl)benzaldehyde (G407010), an impurity of Gleevec (G407000), a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).

Synthesis

Imaric acid 1g (5g, 0.021 mol, Anegi chemical) into 100mL three-necked bottle, add dichlorosulfoxide (35mL) and catalyst N, N-dimethylformamide (0.3mL), heating reflux reaction for 22 hours, reduced to room temperature, pumping and filtration, n-hexane washing (10mL ?? 2), 45 ~ 50 ?? C drying in vacuum for 2 hours, to obtain a white solid state of 4-(4- 4-(4-methylpiperazinylmethyl)benzoyl chloride dihydrochloride (1h) 5.1g, yield 95%.

4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride(106261-64-7)Related Product Information

• Sodium chloride
• p-Toluoyl chloride
• Benzoyl peroxide
• 1-Methylpiperazine
• Methyl salicylate
• Benzoyl chloride
• BENZOYL ISOCYANATE
• Choline chloride
• 2-Fluorobenzoyl chloride
• 2,3,4,5-Tetrafluorobenzoyl chloride
• Tribenuron methyl
• Ammonium chloride
• 3-Methylbenzoyl chloride
• Thiophanate-methyl
• Methyl
• Dihydrochloride
• Methylene Chloride
• 4-Nitrobenzoyl chloride