JX401 Chemical Properties

storage temp. 

Store at RT

solubility 

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

form 

Off-white solid

color 

White

Stability:

Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Hazard Codes 

N

Risk Statements 

50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9/PG 3

JX401 Usage And Synthesis

Description

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.

Uses

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]

Uses

JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.

Definition

ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

storage

Room temperature

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

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