2-(Aminomethyl)-5-methylpyrazine Chemical Properties

Boiling point:

216.2±35.0 °C(Predicted)

Density 

1.09

refractive index 

1.5380-1.5430

storage temp. 

Refrigerator

pka

6.94±0.29(Predicted)

form 

clear liquid

color 

Colorless to Yellow to Green

Specific Gravity

1.09

InChI

InChI=1S/C6H9N3/c1-5-3-9-6(2-7)4-8-5/h3-4H,2,7H2,1H3

InChIKey

MPBCUCGKHDEUDD-UHFFFAOYSA-N

SMILES

C1(CN)=NC=C(C)N=C1

CAS DataBase Reference

132664-85-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-34-41-37/38-22

Safety Statements 

26-36/37/39-39

RIDADR 

2735

HazardClass 

8

PackingGroup 

II

HS Code 

2933998090

2-(Aminomethyl)-5-methylpyrazine Usage And Synthesis

Description

2-(Aminomethyl)-5-methylpyrazine can be used as a pharmaceutical synthesis intermediate, for example, to prepare pyrocatecholamide, which is an antiplatelet drug with a dual inhibitory action. This substance can be prepared from 2,5-dimethylpyrazine as a reaction raw material.

Synthesis

2,5-dimethylpyrazine can be used as a reaction raw material to prepare the intermediate 2-chloromethyl-5-methylpyrazine. It can then be further reacted with sodium iodide and potassium phthalimide to prepare N-((5-methylpyrazine-2-yl)methyl)isoindole-1,3-dione. Finally, it can be reacted with hydrazine hydrate to prepare 2-(Aminomethyl)-5-methylpyrazine.

2-(Aminomethyl)-5-methylpyrazine (132664-85-8)Related Product Information

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