Methanol-d4 Chemical Properties

Melting point:

-99 °C

Boiling point:

65.4 °C(lit.)

Density 

0.888 g/mL at 25 °C(lit.)

vapor pressure 

129 hPa (20 °C)

refractive index 

n20/D 1.326(lit.)

Flash point:

52 °F

storage temp. 

no restrictions.

solubility 

Chloroform (Slightly), Water (Slightly)

form 

Liquid

color 

Colorless

Specific Gravity

0.89

explosive limit

5.5-36.5%(V)

Water Solubility 

Miscible with water, ethanol, ether, acetone and chloroform.

BRN 

1733278

Exposure limits

ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)

Stability:

Stable. Incompatible with moisture, acids, acid chlorides, acid anhydrides, oxidizing agents, reducing agents, alkali metals. Highly flammable.

InChIKey

OKKJLVBELUTLKV-MZCSYVLQSA-N

CAS DataBase Reference

811-98-3(CAS DataBase Reference)

EPA Substance Registry System

Methanol-d4 (811-98-3)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN 1230 3/PG 2

WGK Germany 

1

RTECS 

PC1400000

F 

10-21

Autoignition Temperature

440 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

28459000

Toxicity

LD50 orally in Rabbit: 5628 mg/kg LD50 dermal Rabbit 17100 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Methanol-d4 Usage And Synthesis

Synthesis

A preparation method for providing per-deuterated methanol is provided, specifically: opening the valve of deuterium gas and carbon monoxide, and controlling the volume ratio to be 1:1 to carry out premixing (deuterium gas and carbon monoxide are respectively 2kg and 14kg, a total of 16kg). Under the pressure of 5.5MPa, at a speed of 2L/s, through the catalyst bed layer of gold oxide: platinum oxide: rhodium oxide = 1:3:2 (mass ratio) at 210~380℃, after continuous circulation reaction for 24 hours, in The per-deuterated methanol reaction solution was obtained from the separation kettle, and the obtained reaction solution was rectified to give Methanol-d4: 3.2 kg, yield 35.5%, purity 99.8%.

Chemical Properties

colourless liquid

Uses

Methanol-d4 may be used as a solvent to analyze the rate of exchange of methoxyl group in camphor and norcamphor dimethyl ketals.

Application

Methyl Alcohol-d4 is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR).

Definition

ChEBI: Methanol-d4 is a deuterated compound that is methanol in which all four hydrogen atoms are replaced by deuterium. It is commonly used as a solvent in NMR spectroscopy. It has a role as an amphiprotic solvent.

General Description

Methanol-d₄ (CD₃OD) is a deuterated NMR solvent used for NMR-based research and analyses. It has the highest isotopic enrichment and will not interfere with the desired level of detection.
The absolute infrared absorption intensities of CD3OD have been reported between 8000 and 350cm^-1.

Synthesis

2131312313

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