Imanixil
Imanixil Basic information
- Product Name:
- Imanixil
- Synonyms:
-
- Imanixil
- HOE-402(free base)
- 5-Pyrimidinecarboxamide, 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-N-[3-(trifluoromethyl)phenyl]-
- 4-amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-(3-(trifluoromethyl)phenyl)pyrimidine-5-carboxamide
- 4-Amino-3-ethoxybenzenesulfonic acid
- CAS:
- 75689-93-9
- MF:
- C17H17F3N6O2
- MW:
- 394.35
- Mol File:
- 75689-93-9.mol
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Imanixil Chemical Properties
- Density
- 1.428±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 300 mg/mL (760.75 mM)
- pka
- 10.89±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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Imanixil Usage And Synthesis
Uses
Imanixil (HOE-402 free base) is an inducer of the LDL receptor (LDLR). Imanixil (HOE-402 free base) is also a potent cholesterol-lowering compound, which inhibits very low density-lipoprotein (VLDL) production, and consequently attenuates atherosclerosis development[1].
References
[1] Draijer R, et al. HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice. Biochem Pharmacol. 2002 May 1;63(9):1755-61. DOI:10.1016/s0006-2952(02)00898-5
ImanixilSupplier
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Labnetwork lnc.
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- +86-27-50766799 +8618062016861
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 15801484223;
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Kaifeng Mingren Pharmaceutical Co.,LTD
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- 0371-65741762
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TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com