METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE Chemical Properties

Boiling point:

360.9±42.0 °C(Predicted)

Density 

1.470±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

-3.91±0.25(Predicted)

form 

crystalline solid

color 

Yellow

Safety Information

HS Code 

2922498590

METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 2-amino-6-fluoro-3-nitrobenzoate from methyl 2,6-difluoro-3-nitrobenzoate: Methyl 2,6-difluoro-3-nitrobenzoate (32.55 g, 150 mmol) was dissolved in ethanol (300 mL), followed by the addition of ammonia (13 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the resulting yellow solid product methyl 2-amino-6-fluoro-3-nitrobenzoate (18.31 g, 57% yield) was collected by filtration.

References

[1] Patent: CN104003979, 2016, B. Location in patent: Paragraph 0385; 0388; 0389
[2] Patent: CN103923088, 2016, B. Location in patent: Paragraph 0214; 0216; 0219; 01220
[3] Patent: WO2009/134850, 2009, A1. Location in patent: Page/Page column 16
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2620 - 2623
[5] Patent: US2010/305133, 2010, A1. Location in patent: Page/Page column 12

METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE (346691-23-4)Related Product Information

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