4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties

Boiling point:

362.0±41.0 °C(Predicted)

Density 

1.400±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-0.34±0.20(Predicted)

Appearance

White to yellow Solid-Liquid Mixture

InChI

InChI=1S/C13H16BrNO2/c1-13(2,3)17-12(16)15-8-7-9-10(14)5-4-6-11(9)15/h4-6H,7-8H2,1-3H3

InChIKey

DUZIJTYKDFFQDJ-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)C2=C(C(Br)=CC=C2)CC1

4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis

Uses

4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is an indole derivative used in pharmaceutical synthesis and scientific research.

Synthesis

The reaction mixture was stirred overnight at room temperature in acetonitrile (8 mL) with 4-bromo-2,3-dihydro-1H-indole (759 mg, 3.81 mmol) and di-tert-butyl dicarbonate (976 mg, 4.48 mmol). After completion of the reaction, the solvent was removed by rotary evaporation and the residue was dissolved in ethyl acetate (40 mL). The organic layer was washed sequentially with water (3 x 20 mL) and saturated saline (1 x 20 mL). The organic phase was collected, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, it was purified by silica gel column chromatography (eluent: petroleum ether) to afford N-Boc-4-bromoindoline (840 mg, 74% yield) as a white solid.1H NMR (400 MHz, DMSO-d6) δ 1.50 (s, 9H), 3.02 (t, J = 8.8 Hz, 2H), 3.94 (t, J = 8.8 Hz, 2H) 7.12 (m, 2H), 7.56 (m, 1H).

References

[1] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 225
[2] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0566
[3] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0481
[4] Patent: WO2016/25933, 2016, A2. Location in patent: Page/Page column 185

4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(885272-46-8)Related Product Information

• 4-Bromoindoline
• N-(TERT-BUTOXYCARBONYL)-3-BROMOANILINE
• TERT-BUTYL 2-BROMOPHENETHYLCARBAMATE
• 4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• N-BOC-4-BROMOISATIN