Cidofovir
Cidofovir Basic information
- Product Name:
- Cidofovir
- Synonyms:
-
- Cidofovir hydrate
- Drg-0145
- Gs-0504
- Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S)-
- Unii-jil713Q00n
- (S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate
- Cidofovir hydrate (1:2)
- P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid hydrate (1:2)
- CAS:
- 149394-66-1
- MF:
- C8H14N3O6P
- MW:
- 279.187021
- EINECS:
- 814-987-8
- Product Categories:
-
- Anti-virals
- Heterocyles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Phosphorylating and Phosphitylating Agents
- Amines
- API
- Mol File:
- 149394-66-1.mol
Cidofovir Chemical Properties
- Melting point:
- >250°C (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Sparingly), Water (Sparingly)
- form
- Solid
- color
- White
- InChI
- InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/s3
- InChIKey
- VWFCHDSQECPREK-ISZMHOAENA-N
- SMILES
- N1C(=O)N(C[C@@H](CO)OCP(O)(=O)O)C=CC=1N |&1:5,r|
Cidofovir Usage And Synthesis
Chemical Properties
White Solid
Uses
An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefo re prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
Uses
Cidofovir Dihydrate is used in treatment of pain and combination with analgesics.
Definition
ChEBI: The dihydrate of the anhydrous form of cidofovir. A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
brand name
Vistide (Gilead Sciences).
in vivo
Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) dihydrate is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice[2].
| Animal Model: | Female weanling BALB/c mice infected with cowpox virus (CPV)[2] |
| Dosage: | 100 mg/kg |
| Administration: | Subcutaneous injection; 3-6 days interval; 21 days |
| Result: | Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection. Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day. |
CidofovirSupplier
- Tel
- 021-60951261 18601606476
- nancy@mkpharma.cn
- Tel
- 022-23869539 18920052327
- 281258989@qq.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com