Declopramide Chemical Properties

Boiling point:

404.2±45.0 °C(Predicted)

Density 

1.153±0.06 g/cm3(Predicted)

pka

13.76±0.46(Predicted)

Declopramide Usage And Synthesis

Uses

Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research[1][2][3].

References

[1] Hua J, et al., Comparison of antitumor activity of declopramide (3-chloroprocainamide) and N-acetyl-declopramide. Anticancer Res. 1999 Jan-Feb;19(1A):285-90. PMID:10226556
[2] Hua J, et al., Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. DOI:10.1097/00001813-199901000-00010
[3] Lindgren H, et al., Differential usage of IkappaBalpha and IkappaBbeta in regulation of apoptosis versus gene expression. Biochem Biophys Res Commun. 2003 Jan 31;301(1):204-11. DOI:10.1016/s0006-291x(02)03012-7

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