Lintopride Chemical Properties

Boiling point:

494.1±45.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

13.20±0.46(Predicted)

color 

Light yellow to yellow

Lintopride Usage And Synthesis

Uses

Lintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone[1].

Biological Activity

Lintopride is a 5HT4 antagonist with a slight antagonistic effect on 5HT3.

in vitro

Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride.

target

IC 50

5-HT₄ Receptor; 5-HT₃ Receptor

References

[1] Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DOI:10.1111/j.1365-2036.1995.tb00422.x

Lintopride(107429-63-0)Related Product Information

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