Zylofuramine Chemical Properties

Boiling point:

328.8±15.0 °C(Predicted)

Density 

1.3277 (rough estimate)

refractive index 

1.5240 (estimate)

storage temp. 

Store at -20°C

solubility 

DMSO: ≥ 100 mg/mL (455.95 mM)

form 

Solid

pka

9.35±0.19(Predicted)

color 

White to off-white

Safety Information

Toxicity

LD50 oral in mouse: 475mg/kg

Zylofuramine Usage And Synthesis

Originator

Zylofuramine,ZYF Pharm Chemical

Manufacturing Process

A mixture of furfurylbenzyl ketone and of N-ethyl-α-benzylamine in methanol was hydrogenated over Raney nickel at 150°C and at a pressure of 1500 p.s.i. The catalyst was removed by filtration and the solvent removed by vacuum distillation. The oily residue was taken up in ether, the ether solution washed with dilute hydrochloric acid and the aqueous layer separated. Addition of 35% sodium solution caused the separation of an oil which was taken up in ether. Removal of the ether by evaporation followed by distillation of the residue gave N-ethyl-α-benzyltetrahydrofurfurylamine, boillin point 101°C/0.07 mm.

Therapeutic Function

Psycho-analeptic

Zylofuramine(3563-92-6)Related Product Information

• Zylofuramine
• (R)-(-)-Tetrahydrofurfurylamine