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Sanggenon C

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Sanggenon C Basic information

Product Name:
Sanggenon C
Synonyms:
  • sanggenone
  • Sanggenon C
  • (5aR,10aS)-2-[6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one
  • 2-[(1S)-6β-(2,4-Dihydroxybenzoyl)-5α-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexene-1β-yl]-5a,10a-dihydro-1,3,8,10aβ-tetrahydroxy-5aβ-(3-methyl-2-butenyl)-11H-benzofuro[3,2-b][1]benzopyran-11-one
  • Sanggenone C
  • (5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one
  • 11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-, (5aR,10aS)-
  • (5aR,10aS)-2-((1S,2R,3S)-2-(2,4-Dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-en-1-yl)-5a,10a-dihydro-11H-benzofuro[3,2-b]chromen-11-one
CAS:
80651-76-9
MF:
C40H36O12
MW:
708.71
Product Categories:
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • chemical reagent
  • standardized herbal extract
  • reagent
  • standard substance
  • pharmaceutical intermediate
Mol File:
80651-76-9.mol
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Sanggenon C Chemical Properties

Melting point:
> 240°C (dec.)
Boiling point:
995.5±65.0 °C(Predicted)
Density 
1.512
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Acetone (Slightly), Methanol (Slightly)
pka
6.61±0.60(Predicted)
form 
Solid
color 
Yellow
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Sanggenon C Usage And Synthesis

Description

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 μM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.

Uses

Sanggenone C is a flavanone isolated from Morus plant that showed cytotoxicity against human oral tumor cell lines (HSC-2 and HSG). Sanggenone C is also an inhibitor of protein tyrosine phosphatase 1B.

Definition

ChEBI: Sanggenon C is a diarylheptanoid.

target

NF-kB | NO | NOS | IkB | IKK

Sanggenon CSupplier

Wuhan Huangzhen Biochemical Co., Ltd Gold
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13795480948 13795480948
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Nanjing Dasf Biotechnology Co., Ltd. Gold
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025-+86-02585846866 +86-18094231287
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eric@dasfbio.com
Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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Shenzhen Sungening Bio-Tech Co., Ltd
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+86-0755-89668383
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sales@sungening.com
Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
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