2-aminoadamantane-2-carboxylic acid
2-aminoadamantane-2-carboxylic acid Basic information
- Product Name:
- 2-aminoadamantane-2-carboxylic acid
- Synonyms:
-
- 2-aminoadamantane-2-carboxylic acid
- 2-AMino-2-adaMantanecarboxylic acid
- Tricyclo[3.3.1.13,7]decane-2-carboxylic acid, 2-amino-
- 2-Aminoadamantane-2-carboxylic acid,≥95%
- CAS:
- 42381-05-5
- MF:
- C11H17NO2
- MW:
- 195.26
- Mol File:
- 42381-05-5.mol
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2-aminoadamantane-2-carboxylic acid Chemical Properties
- Boiling point:
- 346.2±25.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.49±0.20(Predicted)
- form
- Solid
- color
- Off-white to brown
- InChI
- InChI=1S/C11H17NO2/c12-11(10(13)14)8-2-6-1-7(4-8)5-9(11)3-6/h6-9H,1-5,12H2,(H,13,14)
- InChIKey
- WQMQRNCPZFUGID-UHFFFAOYSA-N
- SMILES
- C12CC3CC(CC(C3)C1(N)C(O)=O)C2
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Safety Information
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2922498590
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2-aminoadamantane-2-carboxylic acid Usage And Synthesis
Uses
Adamantanine is a γ-turn inducer for peptides. A potential cholecystokinin-B (CCK-B) receptor selective ligands. Also, it inhibits the transport of L-leucine and L-methionine into Ehrlich ascites cells.
Uses
Adamantanine is a γ-turn inducer for peptides. A potential cholecystokinin-B (CCK-B) receptor selective ligands. Also, it inhibits the transport of L-leucine and L-methionine into Ehrlich ascites cells.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 16, p. 823, 1973 DOI: 10.1021/jm00265a016
in vivo
Adamantanine (500 mg/kg, i.p., single dose; 1000 mg/kg, p.o., single dose) is non-toxic in Sprague Dawley rats model as a a finely pulverized suspension[2].
| Animal Model: | Sprague-Dawley rats model[2] |
| Dosage: | 500-1000 mg/kg |
| Administration: | i.p., single dose; p.o., single dose |
| Result: | Exhibited no toxicity. |
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