2,3-Dihydrobenzo[b]furan-5-ylamine Chemical Properties

Melting point:

78-80℃

Boiling point:

289.4±29.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

5.34±0.20(Predicted)

form 

Powder

color 

White to light brown

Water Solubility 

Sparingly soluble in water.(0.26 g/L) (25°C),

Sensitive 

Air Sensitive

CAS DataBase Reference

42933-43-7

Safety Information

HS Code 

2932990090

2,3-Dihydrobenzo[b]furan-5-ylamine Usage And Synthesis

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 18, p. 6681 - 6698
[2] Patent: EP2532665, 2012, A1. Location in patent: Page/Page column 21
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 21, p. 6430 - 6446
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5579 - 5601
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4161 - 4172

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