PULCHINENOSIDE B4 Chemical Properties

Melting point:

208-215℃

Density 

1.48

solubility 

DMSO : 125 mg/mL (102.34 mM; Need ultrasonic)

form 

Powder

pka

12.50±0.70(Predicted)

color 

White to light yellow

InChIKey

OUHBKBTZUPLIIA-UFEMLMIJNA-N

PULCHINENOSIDE B4 Usage And Synthesis

Description

Pulchinenoside B₄ is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B₄ (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B₄ (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the dried roots of Pulsatilla chinensis (Bge.) Regel.

Uses

Pulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory.

References

[1] HE LUAN . Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin[J]. Phytomedicine, 2019, 56: Pages 136-146. DOI: 10.1016/j.phymed.2018.10.035
[2] NAIXIN KANG . Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatilla chinensis in vivo[J]. Phytomedicine, 2019, 64: Article 152934. DOI: 10.1016/j.phymed.2019.152934

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