2-(4-PIPERIDYL)-2-PROPANOL Chemical Properties

Melting point:

136°C

Boiling point:

140-142 °C(Press: 25 Torr)

Density 

0.956±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

15.08±0.29(Predicted)

Appearance

Off-white to yellow Solid

InChI

InChI=1S/C8H17NO/c1-8(2,10)7-3-5-9-6-4-7/h7,9-10H,3-6H2,1-2H3

InChIKey

IIXYTWTZMGUQPT-UHFFFAOYSA-N

SMILES

C(C1CCNCC1)(O)(C)C

CAS DataBase Reference

22990-34-7

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2933399990

2-(4-PIPERIDYL)-2-PROPANOL Usage And Synthesis

Physical Form

Solid

Uses

2-(Piperidin-4-yl)propan-2-ol is a useful research chemical.

Synthesis

Benzyl 4-(1-hydroxy-1-methylethyl)piperidine-1-carboxylate (1.786 g, 6.44 mmol) was used as starting material and dissolved in methanol (100 ml) under nitrogen protection. A 10% palladium-carbon catalyst (50% wet, 1.37 g) was added, followed by replacement of the gas in the reaction system with hydrogen at atmospheric pressure. The reaction mixture was stirred at room temperature for overnight reaction. Upon completion of the reaction, the hydrogen in the reaction system was replaced with nitrogen, then the catalyst was removed by filtration and washed with methanol. The filtrate and washings were combined and the solvent was removed by distillation. Finally, the residue was dried under reduced pressure to afford the target product 2-(4-piperidinyl)-2-propanol (922 mg, 6.44 mmol, quantitative yield) as light gray crystals. The product was characterized by 1H-NMR (CDCl3), δ (ppm): 1.18 (6H, s), 1.26-1.42 (3H, m), 1.74-1.80 (2H, m), 2.57-2.64 (2H, m), 3.14-3.22 (2H, m), 3.48 (1H, s).

References

[1] Patent: EP1522540, 2005, A1. Location in patent: Page/Page column 64
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1935 - 1940

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