6-Ethyl-3-pyridinamine Chemical Properties

Boiling point:

244 °C

Density 

1.037

Flash point:

125 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

6.83±0.10(Predicted)

Appearance

Light yellow to brown Solid-Liquid Mixture

Safety Information

Safety Statements 

24/25

RIDADR 

2810

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29339900

6-Ethyl-3-pyridinamine Usage And Synthesis

Synthesis

The general procedure for the synthesis of 6-ethyl-3-aminopyridine from 5-nitro-2-vinylpyridine is as follows:[Ref. Example 66]; 5-Amino-2-ethylpyridine; 10% palladium-carbon catalyst (50% water moistened, 90 mg) was added to an ethanol solution (30 mL) of 5-nitro-2-vinylpyridine (450 mg), and the reaction was stirred under a hydrogen atmosphere at room temperature for 15 hours. Upon completion of the reaction, the catalyst was removed by filtration. Subsequently, the solvent was evaporated under reduced pressure to afford 6-ethyl-3-aminopyridine as an oily product (359 mg, 98% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 1.25 (3H, t, J=7.5 Hz), 2.71 (2H, q, J=7.5 Hz), 3.32-3.78 (2H, br), 6.91-6.98 (2H, m), 8.02-8.05 (1H, m). Mass spectrum (ESI) m/z: 123 (M+H)+.

References

[1] Patent: EP1591443, 2005, A1. Location in patent: Page/Page column 53

6-Ethyl-3-pyridinamine(126553-00-2)Related Product Information

• 3-Aminopyridine
• 2-Aminopyridine
• 2-Ethoxyethanol
• ISOXADIFEN-ETHYL
• Trinexapac-ethyl
• Ethyl propionate
• Ethyl formate
• Ethyl acetate
• Glycine
• ALTRENOGEST
• 4-Ethylpyridine
• Ethanol
• Ethylparaben
• 4-Dimethylaminopyridine
• 6-Aminocaproic acid
• 2-Aminophenol
• Tris(hydroxymethyl)aminomethane
• Diethyl ether