(S)-(-)-2-Azetidinecarboxylic acid Chemical Properties

Melting point:

~215 °C (dec.)

alpha 

-125 º (c=1, water 25 ºC)

Boiling point:

189.47°C (rough estimate)

Density 

1.2245 (rough estimate)

refractive index 

-122 ° (C=4, H2O)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)

pka

2.35±0.20(Predicted)

form 

Crystalline Powder or Crystals

color 

White to light beige

Water Solubility 

5 g/100 mL

Merck 

14,908

BRN 

80678

InChIKey

IADUEWIQBXOCDZ-VKHMYHEASA-N

CAS DataBase Reference

2133-34-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

RTECS 

CM4310500

Hazard Note 

Irritant

HS Code 

29339900

Hazardous Substances Data

2133-34-8(Hazardous Substances Data)

Toxicity

LD50 scu-mus: 1000 mg/kg 85GDA2 8(1),101,82

MSDS

• Language:English Provider:L-2-Azetidinecarboxylic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(S)-(-)-2-Azetidinecarboxylic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

Specific proline antagonist. Used in synthesis of abnormally high molecular weight polypeptides.

Uses

L-Azetidine-2-carboxylic acid has been used as a:

• collagen synthesis inhibitor
• protein folding antagonist
• as a standard in liquid chromatography-mass spectrometry

Uses

(S)-(-)-2-Azetidinecarboxylic acid is a four-membered ring analog of L-Proline, It is a useful intermediate in the synthesis of polypeptides,Used in synthesis of abnormally high molecular weight polypeptides.

Definition

ChEBI: The (S)-enantiomer of azetidine-2-carboxylic acid.

General Description

L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.

Biochem/physiol Actions

Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.

Safety Profile

Moderately toxic by subcutaneousroute. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

(S)-(-)-2-Azetidinecarboxylic acid(2133-34-8)Related Product Information

• Citric acid
• Calconcarboxylic acid
• Albuterol sulfate
• 2,5-PYRIDINEDICARBOXYLIC ACID
• Cyclobutylamine
• DOBUTAMINE
• ISOBUTANE
• TRIMETHYLENE OXIDE
• AMIKACIN
• Quinolinic acid
• Azetidine
• n-Butane
• Salbutamol
• 1-Chloro-2-methylpropane
• 3-Azetidinecarboxylic acid
• Ascoric Acid
• (S)-BENZYL 2-AZETIDINONE-4-CARBOXYLATE
• 1-Boc-L-azetidine-2-carboxylic acid