3-Pyridinemethanol,2-methoxy-(9CI) Chemical Properties

Melting point:

lowmeltsolid°

Boiling point:

242℃

Density 

1.155

Flash point:

100℃

storage temp. 

Inert atmosphere,Room Temperature

pka

13.20±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

2933399990

3-Pyridinemethanol,2-methoxy-(9CI) Usage And Synthesis

Synthesis

General procedure for the synthesis of (2-methoxy-3-pyridine)methanol from methyl 2-methoxynicotinate: Example 138: Preparation of (2-methoxy-3-pyridine)methanol Methyl 2-methoxy-3-pyridinecarboxylate (1.021 g, 6.11 mmol) was dissolved in anhydrous tetrahydrofuran (5 mL) and lithium borohydride (0.266 g, 1.22 mmol) was added batchwise. The reaction mixture was heated to 70 °C and kept for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride, followed by three extractions with ethyl acetate (3×). The organic phases were combined, dried with magnesium sulfate and concentrated under reduced pressure to give (2-methoxy-3-pyridine)methanol as a colorless oil (0.849 g, 100% yield). 1H-NMR (400 MHz, CDCl3): δ 2.29 (1H, m, OH), 4.0 (3H, s, OCH3), 4.67 (2H, m, CH2), 6.89 (1H, m, Ar-H), 7.59 (1H, m, Ar-H), 8.1 (1H, m, Ar-H) ppm.

References

[1] Patent: WO2007/71900, 2007, A1. Location in patent: Page/Page column 95
[2] Synthetic Communications, 1996, vol. 26, # 12, p. 2257 - 2272
[3] Patent: US2007/49632, 2007, A1. Location in patent: Page/Page column 38
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 18, p. 3386 - 3399
[5] Patent: EP1422228, 2004, A1. Location in patent: Page 205-206

3-Pyridinemethanol,2-methoxy-(9CI)(112197-16-7)Related Product Information

• 2-(4-METHYLPHENOXY)NICOTINIC ACID
• 2,6-Dimethoxypyridine-3-carboxylic acid
• 2-Methoxynicotinic acid
• 2-PHENOXYNICOTINIC ACID
• 2-(4-FLUOROPHENOXY)NICOTINIC ACID
• 2-(4-CHLOROPHENOXY)NICOTINIC ACID
• 2-BENZYLOXY-NICOTINIC ACID
• 2-ETHOXYNICOTINIC ACID
• 3-Pyridinemethanol
• METHYL 2-PHENOXYNICOTINATE
• [2-(4-METHYLPHENOXY)-3-PYRIDINYL]METHYL N-(2-METHYLPHENYL)CARBAMATE
• [2-(4-METHYLPHENOXY)-3-PYRIDINYL]METHANOL
• [2-(4-CHLOROPHENOXY)-3-PYRIDINYL]METHYL N-(4-CHLOROPHENYL)CARBAMATE
• 2-(2,4-dichlorophenoxy)nicotinic acid
• BUTTPARK 82\14-66
• [2-(4-CHLOROPHENOXY)-3-PYRIDINYL]METHYL N-(2-METHYLPHENYL)CARBAMATE
• [2-(4-CHLOROPHENOXY)-3-PYRIDINYL]METHANOL
• 2-(2,4-DIMETHYLPHENOXY)PYRIDINE-3-CARBOXYLIC ACID