2'-O-methyl-2-thiouridine
2'-O-methyl-2-thiouridine Basic information
- Product Name:
- 2'-O-methyl-2-thiouridine
- Synonyms:
-
- 2'-O-methyl-2-thiouridine
- 2-thio-2'-O-methyluridine
- Uridine, 2'-O-methyl-2-thio-
- 2’-O-Methyl-2-thiouridine, RNA-modified nucleoside s2Um
- 2’-O-Methyl-2-thiouridine,
- 2’-O-Methyl-2-thiouridine,?RNA-modified?nucleoside?s2Um
- 2''-O-Methyl-2-thiouridine
- CAS:
- 113886-72-9
- MF:
- C10H14N2O5S
- MW:
- 274.29
- Mol File:
- 113886-72-9.mol
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2'-O-methyl-2-thiouridine Chemical Properties
- Density
- 1.55±0.1 g/cm3(Predicted)
- pka
- 6.97±0.20(Predicted)
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2'-O-methyl-2-thiouridine Usage And Synthesis
Uses
2’-O-Methyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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