hygromycin A Chemical Properties

Melting point:

105-109°; mp 110-112° (dec) (Chida)

alpha 

D25 -126° (c = 1 in water)

Boiling point:

925.5±65.0 °C(Predicted)

Density 

1.60±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 10 mg/mL

form 

A solid

pka

8.9(at 25℃)

color 

White to light yellow

InChIKey

YQYJSBFKSSDGFO-MZHPCZETNA-N

SMILES

[C@H]12OCO[C@H]1[C@@H](O)[C@H](O)[C@H](NC(=O)/C(/C)=C/C1=CC=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](C(=O)C)O3)C(O)=C1)[C@@H]2O |&1:0,4,5,7,9,21,22,24,26,34,r|

CAS DataBase Reference

6379-56-2

hygromycin A Usage And Synthesis

Chemical Properties

White powder. Weakly acidic. Freely soluble in water and alcohol. Produced by Streptomyces hygroscopicus.

Uses

Hygromycin A, a neglected antibiotic, selectively kills the bacteria that cause Lyme disease. It was able to treat Lyme disease in mice without disrupting the microbiome.

Uses

Medicine (broad-spectrum antibiotic).

Definition

ChEBI: A natural product found in Streptomyces species.

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