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hygromycin A

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hygromycin A Basic information

Product Name:
hygromycin A
Synonyms:
  • hygromycin A
  • 5-Deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-5-hexosulofuranosyl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propenyl]amino]-1-O,2-O-methylene-D-neo-inositol
  • Antibiotic WS-1627B
  • Homomycin
  • Hygromycin
  • D-neo-Inositol, 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-β-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-
  • Homomycin A
  • (E)-N-[(3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxol-5-yl]-3-[4-[(2S,3S,4S,5S)-5-acetyl-3,4-dihydroxyoxolan-2-yl]oxy-3-hydroxyphenyl]-2-methylprop-2-enamide
CAS:
6379-56-2
MF:
C23H29NO12
MW:
511.48
Mol File:
6379-56-2.mol
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hygromycin A Chemical Properties

Melting point:
105-109°; mp 110-112° (dec) (Chida)
alpha 
D25 -126° (c = 1 in water)
Boiling point:
925.5±65.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 10 mg/mL
form 
A solid
pka
8.9(at 25℃)
InChIKey
YQYJSBFKSSDGFO-MZHPCZETNA-N
SMILES
[C@H]12OCO[C@H]1[C@@H](O)[C@H](O)[C@H](NC(=O)/C(/C)=C/C1=CC=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](C(=O)C)O3)C(O)=C1)[C@@H]2O |&1:0,4,5,7,9,21,22,24,26,34,r|
CAS DataBase Reference
6379-56-2
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hygromycin A Usage And Synthesis

Chemical Properties

White powder. Weakly acidic. Freely soluble in water and alcohol. Produced by Streptomyces hygroscopicus.

Uses

Hygromycin A, a neglected antibiotic, selectively kills the bacteria that cause Lyme disease. It was able to treat Lyme disease in mice without disrupting the microbiome.

Uses

Medicine (broad-spectrum antibiotic).

Definition

ChEBI: A natural product found in Streptomyces species.

hygromycin ASupplier

Zhejiang Huida Biotech Co., LTD Gold
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Zhejiang Huida Biotech Co., LTD Gold
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Hubei widely chemical technology Co., Ltd.
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027-59402396 13419635609
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13419635609@163.com
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