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thiosemicarbazide

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thiosemicarbazide Basic information

Product Name:
thiosemicarbazide
Synonyms:
  • TSC
  • THIOCARBAMOYL HYDRAZIDE
  • n-aminothiourea
  • 3-thiosemicarbazide
  • AKOS BBS-00004328
  • LABOTEST-BB LT01593682
  • HYDRAZINECARBOTHIOAMIDE
  • Calcineurin B homologous protein 3
CAS:
79-19-6
MF:
CH5N3S
MW:
91.14
EINECS:
201-184-7
Product Categories:
  • Pharmaceutical intermediate
  • Building Blocks
  • Chemical Synthesis
  • Organic Building Blocks
  • Sulfur Compounds
  • Thiocarbonyl Compounds
  • organic sulfide
  • Pharmaceutical Intermediates
  • Indolines ,Indoles
Mol File:
79-19-6.mol
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thiosemicarbazide Chemical Properties

Melting point:
180-183 °C (dec.)(lit.)
Boiling point:
208.6±23.0 °C(Predicted)
Density 
1.221 (estimate)
refractive index 
1.5800 (estimate)
storage temp. 
Poison room
pka
pK1:1.5(+1) (25°C,μ=0.1)
form 
Powder
color 
White to light yellow
PH
5-7 (50g/l, H2O, 20℃)
Water Solubility 
soluble
Merck 
14,9361
BRN 
506320
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
BRWIZMBXBAOCCF-UHFFFAOYSA-N
CAS DataBase Reference
79-19-6(CAS DataBase Reference)
NIST Chemistry Reference
Hydrazinecarbothioamide(79-19-6)
EPA Substance Registry System
Thiosemicarbazide (79-19-6)
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Safety Information

Hazard Codes 
T+
Risk Statements 
28-52/53-26/27/28
Safety Statements 
22-26-36/37-45-61-28A-36/37/39
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
VT4200000
8-9-23
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29309070
HS Code 
29335995
Hazardous Substances Data
79-19-6(Hazardous Substances Data)
Toxicity
LD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949)

MSDS

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thiosemicarbazide Usage And Synthesis

Chemical Properties

white crystalline solid

Chemical Properties

Thiosemicarbazide is an odorless, white crystalline powder.

Uses

As a reagent for detection of metals.

General Description

N-Aminothiourea is a white crystalline powder and is odorless. N-Aminothiourea is used as a reagent for ketones and certain metals, for photography and as a rodenticide. N-Aminothiourea is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. N-Aminothiourea is a chemical intermediate for herbicides and a reagent for detection of metals.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Health Hazard

N-Aminothiourea is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells.

Fire Hazard

When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Potential Exposure

Thiosemicarbazide is a dithiocarbamide compound is used as an intermedialte for pharmaceuticals and herbicides; as a reagent for ketones and certain metals; in certain photography and dye operations; as a rodenticide. It is also effective for control of bacterial leaf blight of rice.

Shipping

UN2771 Thiosemicarbazide, pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise thiosemicarbazide from H2O (solubility is 20.3% w/w at 80o). The hydrochloride has m 190-191o(dec, 184o also reported). It forms salts with heavy metals. [Beilstein 3 H 195, 3 I 79, 3 II 134, 3 III 315, 3 IV 374.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.) and strong reducing agents; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May react with nitrates.

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