thiosemicarbazide Chemical Properties

Melting point:

180-183 °C (dec.)(lit.)

Boiling point:

208.6±23.0 °C(Predicted)

Density 

1.221 (estimate)

vapor pressure 

1.15Pa at 25℃

refractive index 

1.5800 (estimate)

storage temp. 

Store at +15°C to +25°C.

solubility 

DMSO : 125 mg/mL (1371.52 mM; Need ultrasonic)

pka

pK1:1.5(+1) (25°C,μ=0.1)

form 

Powder

color 

White to light yellow

PH

5-7 (50g/l, H2O, 20℃)

Water Solubility 

soluble

Merck 

14,9361

BRN 

506320

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

BRWIZMBXBAOCCF-UHFFFAOYSA-N

LogP

-1.67

CAS DataBase Reference

79-19-6(CAS DataBase Reference)

NIST Chemistry Reference

Hydrazinecarbothioamide(79-19-6)

EPA Substance Registry System

Thiosemicarbazide (79-19-6)

Safety Information

Hazard Codes 

T+

Risk Statements 

28-52/53-26/27/28

Safety Statements 

22-26-36/37-45-61-28A-36/37/39

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

VT4200000

F 

8-9-23

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29309070

HS Code 

29335995

Hazardous Substances Data

79-19-6(Hazardous Substances Data)

Toxicity

LD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949)

MSDS

• Language:English Provider:3-Thiosemicarbazide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

thiosemicarbazide Usage And Synthesis

Chemical Properties

white crystalline solid

Chemical Properties

Thiosemicarbazide is an odorless, white crystalline powder.

Uses

Used in TLC to stain alpha-keto acidsThiosemicarbazide is used as a reagent for ketones as well as chemical intermediate. It is involved in the detection of metals. It is also used in photography. Further, it is effective for controlling bacterial leaf blight in rice. In addition to this, it is used to prepare 1,3,4-thiadiazoles.

Uses

As a reagent for detection of metals.

Definition

ChEBI: Hydrazinecarbothioamide is a member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group. It is a member of hydrazines, a thiocarboxamide and a member of thioureas.

General Description

N-Aminothiourea is a white crystalline powder and is odorless. N-Aminothiourea is used as a reagent for ketones and certain metals, for photography and as a rodenticide. N-Aminothiourea is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. N-Aminothiourea is a chemical intermediate for herbicides and a reagent for detection of metals.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

Health Hazard

N-Aminothiourea is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells.

Fire Hazard

When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Potential Exposure

Thiosemicarbazide is a dithiocarbamide compound is used as an intermedialte for pharmaceuticals and herbicides; as a reagent for ketones and certain metals; in certain photography and dye operations; as a rodenticide. It is also effective for control of bacterial leaf blight of rice.

Shipping

UN2771 Thiosemicarbazide, pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise thiosemicarbazide from H2O (solubility is 20.3% w/w at 80o). The hydrochloride has m 190-191o(dec, 184o also reported). It forms salts with heavy metals. [Beilstein 3 H 195, 3 I 79, 3 II 134, 3 III 315, 3 IV 374.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.) and strong reducing agents; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May react with nitrates.

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