1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Basic information
- Product Name:
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Synonyms:
-
- 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine HCL
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, >=99%
- Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (1:1)
- 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
- MPTP HYDROCHLORIDE
- MPTP
- N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
- MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem
- CAS:
- 23007-85-4
- MF:
- C12H16ClN
- MW:
- 209.72
- Product Categories:
-
- Heterocyclic Compounds
- Neurochemicals
- Mol File:
- 23007-85-4.mol
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties
- Melting point:
- 249.0 to 254.0 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- White solid
- color
- white to off-white
- BRN
- 3707312
- Stability:
- Light Sensitive
- InChIKey
- KOWJANGMTAZWDT-UHFFFAOYSA-N
- CAS DataBase Reference
- 23007-85-4
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25-39/23/24/25-36/37/38
- Safety Statements
- 45-39-26
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- UT8358950
- HS Code
- 2933.39.9200
- HazardClass
- 6.1(b)
- PackingGroup
- III
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
Uses
MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]
Biochem/physiol Actions
Dopaminergic neurotoxin.
Purification Methods
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochlorideSupplier
- Tel
- 021-58958002 18930822973
- SALES@UHNSHANGHAI.COM
- Tel
- 0317-5296180 15533709196
- sale@enkepharma.com
- Tel
- 21-61726900 15202122459
- sales@yunpun.com
- Tel
- 13564747822
- 669027880@qq.com
- Tel
- 021-33632979 15002134094
- marketing@targetmol.com
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride(23007-85-4)Related Product Information
- 4-Pyridineacetic acid hydrochloride
- Topotecan hydrochloride
- 3-Pyridylacetic acid hydrochloride
- 2,6-Lutidine
- Thiophanate-methyl
- Pyridine hydrochloride
- 2,4,6-Collidine
- 2-Pyridylacetic acid hydrochloride
- PHENYL VALERATE
- Bensulfuron methyl
- 4-Methylpyridine
- Kresoxim-methyl
- 4-Phenylpyridine
- Chlorodimethylphenylsilane
- Azamethiphos
- Methylparaben
- Methyl
- Methyl bromide