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4-(Methylsulfonyl)phenol

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4-(Methylsulfonyl)phenol Basic information

Product Name:
4-(Methylsulfonyl)phenol
Synonyms:
  • 4-(METHYLSULFONYL)PHENOL
  • 4-METHYLSULPHONYLPHENOL
  • 4-METHANESULFONYL-PHENOL
  • 4-(methylsulfonyl)-pheno
  • 4-Hydroxyphenyl methyl sulfone
  • 4-hydroxyphenylmethylsulfone
  • p-(methylsulfonyl)-pheno
  • p-(Methylsulfonyl)phenol
CAS:
14763-60-1
MF:
C7H8O3S
MW:
172.2
EINECS:
632-596-9
Mol File:
14763-60-1.mol
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4-(Methylsulfonyl)phenol Chemical Properties

Melting point:
90-95 °C
Boiling point:
272.52°C (rough estimate)
Density 
1.3692 (rough estimate)
refractive index 
1.5151 (estimate)
RTECS 
SM1530000
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO, Methanol
form 
Powder
pka
pK1:7.83 (25°C)
color 
Tan to pink-brown
Water Solubility 
slight
BRN 
1866322
LogP
0.886 (est)
CAS DataBase Reference
14763-60-1(CAS DataBase Reference)
NIST Chemistry Reference
4-(Methylsulfonyl)phenol(14763-60-1)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
24/25-26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29309090

MSDS

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4-(Methylsulfonyl)phenol Usage And Synthesis

Chemical Properties

Tan to pink-brown powder

Uses

4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

Reactions

The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).

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