4-amidinoindan-1-one 2'-amidinohydrazone
4-amidinoindan-1-one 2'-amidinohydrazone Basic information
- Product Name:
- 4-amidinoindan-1-one 2'-amidinohydrazone
- Synonyms:
-
- 4-amidinoindan-1-one 2'-amidinohydrazone
- (E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
- (E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec
- SardoMozide
- CGP 48664
- SAM 486A
- 2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide
- Hydrazinecarboximidamide, 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-
- CAS:
- 149400-88-4
- MF:
- C11H14N6
- MW:
- 230.274
- Mol File:
- 149400-88-4.mol
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4-amidinoindan-1-one 2'-amidinohydrazone Chemical Properties
- Boiling point:
- 438.8±55.0 °C(Predicted)
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO
- pka
- 11.54±0.20(Predicted)
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4-amidinoindan-1-one 2'-amidinohydrazone Usage And Synthesis
Biological Activity
Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with IC50 of 5 nM.
in vitro
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.
target
IC50: 5 nM (SAMDC)
4-amidinoindan-1-one 2'-amidinohydrazoneSupplier
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