inulicin
inulicin Basic information
- Product Name:
- inulicin
- Synonyms:
-
- (3aS)-3,3aα,4,5,8,8aα-Hexahydro-4α-hydroxy-6-(3-acetoxypropyl)-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
- (3aS)-6-(3-Acetoxypropyl)-3,3aα,4,5,8,8aα-hexahydro-4α-hydroxy-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
- Britannilactone
- (3aS,4S,7aR)-5-[(1S)-4-(Acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone
- inulicin
- 6-(3-acetoxy-propyl)-4-hydroxy-5,7-dimethyl-3-methylene-3,3a,4,5,8,8a-hexahydro-cyclohepta[b]furan-2-one
- 1-O-Acetylbritannilactone (Inulicin)
- 2(3H)-Benzofuranone,5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-,(3aS,4S,7aR)-
- CAS:
- 33627-41-7
- MF:
- C17H24O5
- MW:
- 308.37
- Mol File:
- 33627-41-7.mol
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inulicin Chemical Properties
- Melting point:
- 124.0-126.1 °C
- Boiling point:
- 481.7±45.0 °C(Predicted)
- Density
- 1.16
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 13.71±0.60(Predicted)
- color
- White to off-white
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inulicin Usage And Synthesis
Biological Activity
Inulicin (1-O-Acetylbritannilactone) is an active compound isolated from Inula Britannica L. It inhibits VEGF-mediated activation of Src and FAK. It also inhibits LPS-induced PGE2 production and COX-2 expression, as well as NF-κB activation and translocation.
in vivo
Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied.
target
| NF-κB < span> | COX-2
|
inulicinSupplier
BioBioPha Co., Ltd.
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Shanghai Tauto Biotech Co., Ltd.
- Tel
- 021-51320588
- tauto@tautobiotech.com
Chengdu Herbpurify Co.Ltd.
- Tel
- 18302802153 18981717076
- 2355253619@qq.com
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inulicin(33627-41-7)Related Product Information
- Curcumol
- Curcumenol
- 1-O-acetyl Britannilactone
- 1-Caffeoylquinic acid
- β-Caryophyllene
- Cynarin
- ERGOLIDE
- Curdione
- alpha-Cyperone
- 1,6-Dihydroxyeriolanolide
- CYNARIN
- 1,6-O,O-diacetylbritannilactone
- (CIS)-8-METHYLNON-6-ENOIC ACID
- 3,7-DIMETHYL-2-METHYLENE-OCT-6-ENAL
- inulicin
- CITRONELLIC ACID
- 5-METHYL-3-METHYLENE-DIHYDRO-FURAN-2-ONE
- 5-ETHYL-3-METHYLENE-DIHYDRO-FURAN-2-ONE