ChemicalBook > Product Catalog > Biochemical Engineering > Plant extracts > Plant Extracts > 1',2'-dihydrorotenone
1',2'-dihydrorotenone
1',2'-dihydrorotenone Basic information
- Product Name:
- 1',2'-dihydrorotenone
- Synonyms:
-
- 1',2'-dihydrorotenone
- (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
- (2R)-1,2,12,12aα-Tetrahydro-2α-isopropyl-8,9-dimethoxy[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aαH)-one
- Dihydrorotenone
- NSC 351138
- NSC 53866
- 2R,6aS,12aS-2-isopropyl-8,9-dimethoxy-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one
- dihydrorotenone standard
- CAS:
- 6659-45-6
- MF:
- C23H24O6
- MW:
- 396.43
- Mol File:
- 6659-45-6.mol
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1',2'-dihydrorotenone Chemical Properties
- Melting point:
- 216℃
- Boiling point:
- 553.9±50.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- EPA Substance Registry System
- 1',2'-Dihydrorotenone (6659-45-6)
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1',2'-dihydrorotenone Usage And Synthesis
Uses
Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway[1].
References
[1] Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911. DOI:10.1371/journal.pone.0069911
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