KB 3022
KB 3022 Basic information
- Product Name:
- KB 3022
- Synonyms:
-
- KB 3022
- 2-[4,5-Bis(4-methoxyphenyl)thiazol-2-yl]-1H-pyrrole-1-acetic acid ethyl ester
- KBT-3022
- ethyl 2-(2-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1H-pyrrol-1-yl)acetate
- ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]-pyrrole-1-acetate
- KB3022 (KBT3022
- 1H-Pyrrole-1-acetic acid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester
- Cyclooxygenase,KBT-3022,Pamicogrel,Inhibitor,inhibit,KBT 3022,COX
- CAS:
- 101001-34-7
- MF:
- C25H24N2O4S
- MW:
- 448.53
- Mol File:
- 101001-34-7.mol
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KB 3022 Chemical Properties
- Melting point:
- 132.5-135.5°
- Boiling point:
- 600.3±65.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:10.0(Max Conc. mg/mL);22.0(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM) - form
- A crystalline solid
- pka
- 2.68±0.10(Predicted)
- color
- Off-white to pink
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KB 3022 Usage And Synthesis
Uses
Pamicogrel (KBT3022) is a cyclooxygenase (COX) inhibitor.
Biological Activity
Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregation properties.
in vitro
KB 3022 is a cyclooxygenase inhibitor with platelet anti-aggregatory properties which is under development by Kanebo for chronic arterial occlusion. It also has potential in both prophylaxis and treatment of ischemic brain injury.