pinusolide Chemical Properties

Melting point:

82-84 °C(Solv: ligroine (8032-32-4))

Boiling point:

465.3±38.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

InChI

InChI=1S/C21H30O4/c1-14-6-9-17-20(2,11-5-12-21(17,3)19(23)24-4)16(14)8-7-15-10-13-25-18(15)22/h10,16-17H,1,5-9,11-13H2,2-4H3/t16-,17+,20+,21-/m0/s1

InChIKey

WTKBZJAWPZXKJU-NLEAXPPASA-N

SMILES

[C@]1(C)(C(OC)=O)[C@@]2([H])[C@@](C)([C@@H](CCC3=CCOC3=O)C(=C)CC2)CCC1

LogP

4.520 (est)

pinusolide Usage And Synthesis

Uses

Pinusolide is a known platelet-activating factor (PAF) receptor binding antagonist. Pinusolide not only decreases the proliferation activity of tumor cells but specifically induces apoptosis[1].

Definition

ChEBI: A natural product found in Biota orientalis.

target

AMPK | LOX | Calcium Channel | JNK | ERK | p38MAPK | Caspase

References

[1] Shults EE, et al. Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential. Bioorg Med Chem Lett. 2006;16(16):4228-4232. DOI:10.1016/j.bmcl.2006.05.077

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