GOITRINE Chemical Properties

Melting point:

47.5°C

Boiling point:

150.6±43.0 °C(Predicted)

Density 

1.170 (estimate)

refractive index 

1.5480 (estimate)

storage temp. 

Amber Vial, -20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

solid

pka

13.34±0.40(Predicted)

color 

White to Off-White

Safety Information

Safety Statements 

24/25

HS Code 

29349990

Toxicity

mouse,LD50,unreported,1260mg/kg (1260mg/kg),Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 483, 1969.

GOITRINE Usage And Synthesis

Uses

Goitrine is a cyclic thiocarbamate that is seen reducing production of thyroid hormones.

Definition

ChEBI: (R)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent and a plant metabolite. It is an enantiomer of a (S)-goitrin.

Biological Activity

Epigoitrin is a sulfur containing alkaloid isolated from Isatis indigotica (Ban Lan Gen) th at exhibits antiviral, anticancer, and antithyroid activities. Epigoitrin significantly decreases the susceptibility of restraint mice to H1N1 influenza virus. Epigoitrin and goitrin appear to show virucidal effect on influenza virus A (H1N1) in vitro and in ovo.

target

Influenza virus

GOITRINE(1072-93-1)Related Product Information

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