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(3R)-8-hydroxy-3-methyl-isochroman-1-one

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(3R)-8-hydroxy-3-methyl-isochroman-1-one Basic information

Product Name:
(3R)-8-hydroxy-3-methyl-isochroman-1-one
Synonyms:
  • (3R)-8-hydroxy-3-methyl-isochroman-1-one
  • (R)-3,4-Dihydro-3-methyl-8-hydroxyisocoumarin
  • (R)-3,4-Dihydro-8-hydroxy-3-methyl-1H-2-benzopyran-1-one
  • [R,(-)]-3,4-Dihydro-3α-methyl-8-hydroxyisocoumarin
  • (R)-(-)-Mellein, (S)-(+)-Mellein
  • (R)-()-Mellein
  • 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-methyl-, (3R)-
CAS:
480-33-1
MF:
C10H10O3
MW:
178.18
EINECS:
200-258-5
Mol File:
480-33-1.mol
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(3R)-8-hydroxy-3-methyl-isochroman-1-one Chemical Properties

Melting point:
58-58.5 °C
Boiling point:
392.7±42.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
9.86±0.40(Predicted)
CAS DataBase Reference
480-33-1
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(3R)-8-hydroxy-3-methyl-isochroman-1-one Usage And Synthesis

Uses

(R)-(?)-Mellein is a dihydroisocoumarin compound produced by A. ochraceus Wilhelm. It has a variety of biological activities including antibacterial, antimalarial, antifungal, and anticancer effects. (R)-(?)-Mellein inhibits proliferation of human breast cancer (MCF-7 and MDA-MB-468) and melanoma (SK-MEL-28 and Malme-3M) cell lines with IC50 values greater than 200 μM.[Cayman Chemical]

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