(4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical Properties

Boiling point:

636.8±55.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

pka

4.27±0.60(Predicted)

(4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Usage And Synthesis

Uses

Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa[1].

References

[1] Mohammed I El-Gamal, et al. Current status of carbapenem antibiotics. Curr Top Med Chem. 2010;10(18):1882-97. DOI:10.2174/156802610793176639

(4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid(149951-16-6)Related Product Information

• (AZETIDIN-3-YL)METHANOL
• 4-Propyl-2-azetidinone
• RARECHEM AL CA 0256
• 2-(dibutylamino)acetic acid
• (4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• 4-Isopropyl-2-azetidinone