4-IODO-2-PYRIDONE Chemical Properties

Melting point:

186-188°C

Boiling point:

321.6±35.0 °C(Predicted)

Density 

2.12±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

solid

pka

10.76±0.10(Predicted)

color 

Pale brown

CAS DataBase Reference

858839-90-4

Safety Information

HS Code 

2933399990

4-IODO-2-PYRIDONE Usage And Synthesis

Synthesis

GENERAL METHOD: 2-chloro-4-iodopyridine (prepared above) was heated with sodium acetate (2.0 eq.) in 1.0 M acetic acid solution at 150°C for 72 hours in a sealed tube. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was partitioned between ethyl acetate (3 mL/mmol) and cold water (3 mL/mmol). The aqueous layer was extracted with ethyl acetate (3 mL/mmol; 4 times). The combined organic layers were washed sequentially with saturated NaHCO3 solution (1 mL/mmol), brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford 4-iodo-2-pyridinone (1b/c/d), details of the specific compound are given below.

References

[1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Patent: US2010/331320, 2010, A1. Location in patent: Page/Page column 89; 90
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 48
[4] Patent: WO2012/32014, 2012, A1. Location in patent: Page/Page column 94
[5] Patent: US2012/214782, 2012, A1. Location in patent: Page/Page column 40

4-IODO-2-PYRIDONE(858839-90-4)Related Product Information

• 4-HYDROXYPYRIDINE
• ALLYL IODIDE
• 4-IODO-2-PYRIDONE