6-AMINO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID Chemical Properties

Melting point:

176-178 °C

Boiling point:

387.9±42.0 °C(Predicted)

Density 

1.569±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.35±0.20(Predicted)

Appearance

Yellow to brown Solid

6-AMINO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-aminobenzo[d][1,3]dioxole-5-carboxylic acid from methyl 6-aminobenzo[d][1,3]dioxole-5-carboxylate: Sodium hydroxide (2.95 g, 73.8 mmol) was added to water (75 mL), and stirred until completely dissolved. Methyl 6-aminobenzo[d][1,3]dioxole-5-carboxylate (12.0 g, 61.5 mmol) was then added and the reaction mixture was heated to 90°C and stirred for 2 hours. After completion of the reaction, the reaction mixture was cooled with ice water and the pH was adjusted to 2 with concentrated hydrochloric acid to precipitate a solid. The mixture was stirred thoroughly and filtered, the filter cake was washed with water and dried to give 6-aminobenzo[d][1,3]dioxole-5-carboxylic acid (7.2 g, 65% yield).

References

[1] Patent: CN104557955, 2017, B. Location in patent: Paragraph 0152; 0156

6-AMINO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID(20332-16-5)Related Product Information

• 6-NITRO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID
• methyl 6-amino-1,3-benzodioxole-5-carboxylate
• CBI-BB ZERO/005500
• RARECHEM AL BI 0176
• 6-AMINO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID