2-Hydroxy-2-methylpropiophenone Chemical Properties

Melting point:

4°C

Boiling point:

102-103 °C4 mm Hg(lit.)

Density 

1.077 g/mL at 25 °C(lit.)

vapor pressure 

0.57Pa at 20℃

refractive index 

n20/D 1.533(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Practically insoluble in water

form 

clear liquid

pka

13.23±0.29(Predicted)

Specific Gravity

1.077

color 

Colorless to Light orange to Yellow

Water Solubility 

13.3g/L at 20℃

InChIKey

XMLYCEVDHLAQEL-UHFFFAOYSA-N

LogP

1.62 at 25℃

CAS DataBase Reference

7473-98-5(CAS DataBase Reference)

EPA Substance Registry System

1-Propanone, 2-hydroxy-2-methyl-1-phenyl- (7473-98-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

23-36/37/39

RIDADR 

3082

WGK Germany 

3

RTECS 

UC2977245

HazardClass 

9

PackingGroup 

III

HS Code 

29144000

MSDS

• Language:English Provider:SigmaAldrich

2-Hydroxy-2-methylpropiophenone Usage And Synthesis

Uses

2-Hydroxy-2-methylpropiophenone is a photoinitiator.In addition, 2-hydroxy-2-methylpropiophenone is an important organic intermediate (building block) to synthetize substituted propiophenone products.

Chemical Properties

Yellowish clear liquid

Uses

2-Hydroxy-2-benzoylpropane was used as a catalyst in real-time kinetic study of laser-induced polymerization. It is also a photoinitiator.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4365, 1988 DOI: 10.1016/S0040-4039(00)80496-7

General Description

2-Hydroxy-2-methylpropiophenone is a radical photoinitiator (PI) molecule that can be used in the crosslinking of polymers by the exposure of UV radiation. It can be used in the development of UV curable resins for exterior coating applications.

Hazard

Moderately toxic by ingestion.

Flammability and Explosibility

Not classified

Synthesis

KBr in water is added to a solution of 2-methyl-1-phenylpropane-1,2-diol in toluene. Then, TEMPO is added. The reddish suspension is cooled to 0°C. A 12 % sodium hypochlorite solution is added while maintaining the internal temperature at 5°C or lower. The mixture is stirred for 1 h at 0-5°C and then separated for 10 min. Sodium dithionite solution (obtained from 30 g sodium dithionite (85%) and 400 ml of water)is added to the organic phase and stirred at 85°C for 1-2 h. The organic phase is again separated and concentrated (rotavap). The crude product is then subjected to fractional distillation, yielding 2-Hydroxy-2-methylpropiophenone as a colorless oil.

2-Hydroxy-2-methylpropiophenone(7473-98-5)Related Product Information

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• 1-(4-ISOPROPYLPHENYL)-2-HYDROXY-2-METHYL-1-PROPANONE