2-(4-Hydroxypenyl)pyridine Chemical Properties

Melting point:

164-165 °C(Solv: benzene (71-43-2))

Boiling point:

185-188 °C(Press: 4 Torr)

Density 

1.169±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

8.72±0.13(Predicted)

color 

Pink

CAS DataBase Reference

51035-40-6(CAS DataBase Reference)

Safety Information

HS Code 

2933399990

2-(4-Hydroxypenyl)pyridine Usage And Synthesis

Chemical Properties

White crystals

Synthesis

GENERAL METHOD: A mixture of aryl ketone (1.0 mmol, here p-hydroxyacetophenone), 1,3-propanediamine (1.3 mmol) and p-toluenesulfonic acid (1.0 mmol) was stirred in THF under oxygen atmosphere. Subsequently Pd(OAc)2 (0.1 mmol) was added and the reaction mixture was heated to reflux temperature and maintained for 8-12 hours. Upon completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting concentrate was diluted with water and extracted with ethyl acetate. The ethyl acetate layer was washed with Na2S2O3 solution, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure to give the crude product. Finally, the target product 2-(4-hydroxyphenyl)pyridine was purified by silica gel column chromatography (eluent: hexane-ethyl acetate mixed solvent).

References

[1] Chemical Communications, 2016, vol. 52, # 5, p. 1009 - 1012
[2] Tetrahedron Letters, 2017, vol. 58, # 6, p. 524 - 526
[3] Organic Letters, 2014, vol. 16, # 20, p. 5269 - 5271
[4] RSC Advances, 2016, vol. 6, # 54, p. 48315 - 48318

2-(4-Hydroxypenyl)pyridine(51035-40-6)Related Product Information

• Triphenylphosphine
• 2-Chloro-3-cyanopyridine
• Chromium picolinate
• Hydroxy silicone oil
• Sulfasalazine
• 1-Phenyl-2-nitropropene
• 4-Cyanophenol
• 4-Hydroxypyridine
• Pyridine
• Palmatine chloride hydrate
• BERBERINE SULFATE TRIHYDRATE
• BERBERINE CHLORIDE DIHYDRATE
• Coptisine chloride
• 6,7-DIMETHOXY-1-(3,4,5-TRIETHOXYPHENYL)ISOQUINOLINE
• Palmatine chloride
• Phenylacetone
• 2-(4-METHOXYPHENYL)PYRIDINE
• 2-(4-METHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID