5-bromo-6-chloropyridin-2-amine Chemical Properties

Boiling point:

285℃

Density 

1.834

Flash point:

126℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

1.21±0.10(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C5H4BrClN2/c6-3-1-2-4(8)9-5(3)7/h1-2H,(H2,8,9)

InChIKey

BUTBOALODZMXJV-UHFFFAOYSA-N

SMILES

C1(N)=NC(Cl)=C(Br)C=C1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

2811

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2933399990

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

5-bromo-6-chloropyridin-2-amine Usage And Synthesis

Uses

2-Amino-6-chloro-5-bromopyridine can be used as a pharmaceutical synthesis intermediate.

Synthesis

Weighed 6-chloro-pyridin-2-amine (2.58g,20.06mmol), added to N,N-dimethylformamide (25mL) was dissolved, weighed N-bromosuccinimide (3.56g,20.00mmol) was added to the above solution, and the reaction was done at room temperature for 0.5 hours. Water was added, extracted with ethyl acetate, the organic phase was washed with saturated brine, dried with anhydrous sodium sulfate, concentrated, and the crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate = 5:1) to give the title compound (3.60 g, 86.5% yield).

5-bromo-6-chloropyridin-2-amine(358672-65-8)Related Product Information

• 2-Chloro-3-bromo-5-aminopyridine
• 2-Pyridinamine, 5-bromo-4-chloro-
• 4-Bromopyridine hydrochloride
• Pyridinium tribromide
• 3-Pyridyl bromide
• 2-Bromopyridine