4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Chemical Properties

Melting point:

230(dec.)

Boiling point:

230 °C/dec)

Density 

1.309±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.77±0.20(Predicted)

form 

solid

color 

Light brown

Safety Information

Hazard Codes 

Xi,C

HazardClass 

IRRITANT

HS Code 

2902900000

4-[(4-METHYLPHENYL)SULFONYL]PIPERIDINE HYDROCHLORIDE Usage And Synthesis

Synthesis

Methyl 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate (320 mg, 1.57 mmol) was used as a raw material and dissolved in a solvent mixture of 6 mL of methanol and 3 mL of water. Subsequently, lithium hydroxide (331 mg, 7.88 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that the reaction was complete, the pH of the reaction solution was adjusted to 5 with 1 N hydrochloric acid solution.The reaction solution was concentrated by rotary evaporation and extracted with ethyl acetate (50 mL × 2). The ethyl acetate extracts were combined and the solvent was removed by rotary evaporation to afford the white solid product 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (310 mg, 100% yield).

References

[1] Patent: CN104844471, 2017, B. Location in patent: Paragraph 0186; 0187; 0188

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