TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Chemical Properties

Melting point:

88-90℃

Boiling point:

288.7±40.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

-3.61±0.40(Predicted)

color 

White to Light yellow

InChI

InChI=1S/C10H16FNO3/c1-10(2,3)15-9(14)12-5-4-8(13)7(11)6-12/h7H,4-6H2,1-3H3

InChIKey

JZNWQLLPLOQGOI-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC(=O)C(F)C1

CAS DataBase Reference

211108-50-8

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-52

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE Usage And Synthesis

Uses

Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is a versatile compound that finds frequent application in chemical synthesis procedures. This compound serves as a valuable building block due to its unique structural properties and reactivity. Within the realm of organic synthesis, Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is commonly used as a key intermediate in the preparation of various pharmaceuticals, agrochemicals, and fine chemicals.
This compound undergoes a variety of selective reactions, enabling chemists to introduce functional groups at specific positions on the piperidine ring. Its tert-butyl ester group provides steric hindrance, influencing the compound's reactivity and selectivity in subsequent transformations. Additionally, the presence of a fluoro substituent enhances the compound's electronic properties, enabling it to participate in diverse synthetic strategies.Researchers leverage the unique structural features of Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate to access complex molecular architectures efficiently. By incorporating this compound into their synthetic routes, chemists can streamline the synthesis of intricate molecules and accelerate the discovery of novel bioactive compounds. In summary, the versatile nature of Tert-Butyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate makes it an indispensable tool in modern chemical synthesis endeavors.

Synthesis

Tert-butyl 4-(trimethylsilyloxy)-5,6-dihydropyridine-1(2H)-carboxylate (25.0 g, 0.09 mol) was used as a raw material, which was dissolved in anhydrous acetonitrile (200 mL), and 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (35.8 g, 0.101 mol) was added under stirring. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction solution was diluted with ethyl acetate and subsequently washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel fast column chromatography to afford tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate as an off-white solid in 73% yield (8.1 g). The product was analyzed by LCMS (Method C): m/z 118.2 (M-Boc + H), retention time 2.53 min, purity 96.5% (ELSD).1H NMR (400 MHz, DMSO-d6) δ: 4.92-4.89 (m, 1H), 4.76-4.73 (m, 1H), 4.21-4.17 (m, 1H). 3.30-3.20 (m, 2H), 2.60-2.45 (m, 2H), 1.47 (s, 9H).

References

[1] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 15, p. 2667 - 2670
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 12, p. 2087 - 2104
[4] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 223
[5] Patent: US2006/258721, 2006, A1. Location in patent: Page/Page column 74; 75

TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE(211108-50-8)Related Product Information

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