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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic information

Product Name:
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonyms:
  • 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-ACETAMIDE
  • N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO
  • MSTFA MSTFA
  • 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide for gas chromatography
  • N-METHYL-N-TMS-TRIFLUOROACETAMIDE
  • N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE
  • N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED I
  • N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED II
CAS:
24589-78-4
MF:
C6H12F3NOSi
MW:
199.25
EINECS:
246-331-6
Product Categories:
  • Silylation (GC Derivatizing Reagents)
  • Si-N Compounds
  • Trimethylsilylation (GC Derivatizing Reagents)
  • Reagents for SilylationProtection and Derivatization
  • Silicon-BasedAnalytical/Chromatography
  • Protecting and Derivatizing Reagents
  • Silylation Reagents
  • Derivatization Reagents
  • Derivatization Reagents GC
  • Reagents for SilylationAnalytical/Chromatography
  • Amines
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Analytical Chemistry
  • GC Derivatizing Reagents
  • Si (Classes of Silicon Compounds)
  • Silylacetamides
  • Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Silylation Reagents
Mol File:
24589-78-4.mol
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties

Melting point:
98-100°C
Boiling point:
130132°C
Density 
1.075 g/mL at 25 °C(lit.)
vapor density 
>1 (vs air)
vapor pressure 
8.8 mm Hg ( 27 °C)
refractive index 
n20/D 1.383
Flash point:
77 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear colorless to light yellow
Specific Gravity
1.076
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
BRN 
1941550
InChIKey
MSPCIZMDDUQPGJ-UHFFFAOYSA-N
CAS DataBase Reference
24589-78-4(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, 2,2,2-trifluoro-N-methyl-N-( trimethylsilyl)-(24589-78-4)
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Safety Information

Hazard Codes 
Xi,F,T,N
Risk Statements 
10-36/37/38-61-50/53-51/53
Safety Statements 
26-36-37/39-16-45-53-61
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
AC9800000
10-21
Hazard Note 
Flammable
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29319090

MSDS

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N-Methyl-N-(trimethylsilyl)trifluoroacetamide Usage And Synthesis

Chemical Properties

Clear colorless to light yellow liquid

Uses

A new metabolite of Famprofazone in humans.

Uses

pharmaceutical intermediate

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

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