N-Methyl-N-(trimethylsilyl)trifluoroacetamide
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic information
- Product Name:
- N-Methyl-N-(trimethylsilyl)trifluoroacetamide
- Synonyms:
-
- N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE W. 1% TMCS
- N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO-ACE TAMIDE, DERIVATIZATION GRADE
- N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACET-A MIDE, FOR GC
- N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAM, 10x1ML PACKSIZE
- N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 98%
- N-Methyl-N-(Trimethylsily)Trifluoroacetamide
- N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 98
- MSTFA~N-Trimethylsilyl-N-methyltrifluoroacetamide
- CAS:
- 24589-78-4
- MF:
- C6H12F3NOSi
- MW:
- 199.25
- EINECS:
- 246-331-6
- Product Categories:
-
- Silylation Reagents
- Amines
- Silylation (GC Derivatizing Reagents)
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Si-N Compounds
- Trimethylsilylation (GC Derivatizing Reagents)
- Silylation Reagents
- Derivatization Reagents
- Derivatization Reagents GC
- Reagents for SilylationProtection and Derivatization
- Silicon-BasedAnalytical/Chromatography
- Protecting and Derivatizing Reagents
- Analytical Chemistry
- GC Derivatizing Reagents
- Si (Classes of Silicon Compounds)
- Silylacetamides
- Reagents for SilylationAnalytical/Chromatography
- Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 24589-78-4.mol
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties
- Melting point:
- 98-100°C
- Boiling point:
- 130132°C
- Density
- 1.075 g/mL at 25 °C(lit.)
- vapor density
- >1 (vs air)
- vapor pressure
- 8.8 mm Hg ( 27 °C)
- refractive index
- n20/D 1.383
- Flash point:
- 77 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- -1.34±0.70(Predicted)
- form
- Liquid
- color
- Clear colorless to light yellow
- Specific Gravity
- 1.076
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 1941550
- InChIKey
- MSPCIZMDDUQPGJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 24589-78-4(CAS DataBase Reference)
- EPA Substance Registry System
- Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)
Safety Information
- Hazard Codes
- Xi,F,T,N
- Risk Statements
- 10-36/37/38-61-50/53-51/53
- Safety Statements
- 26-36-37/39-16-45-53-61
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- RTECS
- AC9800000
- F
- 10-21
- Hazard Note
- Flammable
- TSCA
- T
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29319090
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Usage And Synthesis
Chemical Properties
Clear colorless to light yellow liquid
Uses
A new metabolite of Famprofazone in humans.
Uses
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
Definition
ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.
General Description
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.
Purification Methods
Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide(24589-78-4)Related Product Information
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- N-(Trimethylsilyl)acetamide
- Mstfa Reagent