Bismuth subnitrate Chemical Properties

Melting point:

260°C

Density 

4.928

vapor pressure 

0Pa at 20℃

storage temp. 

Store at +5°C to +30°C.

solubility 

Practically insoluble in water and in ethanol (96 per cent). It dissolves in mineral acids with decomposition.

form 

Powder/Solid

color 

White

PH

3.2 (50g/l, H2O, 20℃)(slurry)

Water Solubility 

Practically insoluble in water and alcohol. Soluble in dilute HNO{3} and HCl

Sensitive 

Hygroscopic

Merck 

14,1284

Stability:

Stability Strong oxidizer - contact with combustible material may lead to fire. Incompatible with reducing agents, organic materials.

CAS DataBase Reference

1304-85-4(CAS DataBase Reference)

EPA Substance Registry System

Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) (1304-85-4)

Safety Information

Hazard Codes 

O,Xi

Risk Statements 

8-36/37/38

Safety Statements 

17-26-36/37/39-36

RIDADR 

UN 1477 5.1/PG 2

WGK Germany 

3

RTECS 

EB2977000

F 

8

TSCA 

Yes

HS Code 

2834 29 80

HazardClass 

5.1

PackingGroup 

II

Hazardous Substances Data

1304-85-4(Hazardous Substances Data)

Toxicity

infant,LDLo,oral,1gm/kg (1000mg/kg),"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 134, 1969.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Bismuth subnitrate Usage And Synthesis

Description

Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.

Bismuth Subnitrate is a basic salt that contains the equivalent of not less than 79.0 percent of bismuth trioxide (Bi2O3),calculated on the dried basis.It is both odorless and tasteless, and is used in bleaching and freckle creams, and hair dyes.
Bismuth subnitrate has been used to induce metallothionein in heart tissue and kidneys and to attenuate the toxicity of Adriamycin and cisplatin compounds, respectively.

Chemical Properties

White, heavy, Slightly hygroscopic powder

Uses

manufacture of bismuth fluxes for enamels; in cosmetics.

Uses

Bismuth subnitrate (BiNO3) is used in the cosmetics industry and to make ceramic and enamel glazes.

Uses

It is used pharmaceutically in wound dressing, ointment component and as an antiacid. In cosmetics it is used as a cosmetic white pigment. Used in Ceramic glazes and enamel fluxes.

brand name

Mammol (Abbott).

Flammability and Explosibility

Non flammable

Pharmacology

Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa. In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers. In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective. In a randomized clinical study consisting of patients with H. pylori-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of H. pylori.

Mode of action

Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease. Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH.

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