2-Pyridinethiol 1-oxide Chemical Properties

Melting point:

69-72 °C (lit.)

Boiling point:

350.2±15.0 °C(Predicted)

Density 

1.255 (estimate)

refractive index 

1.5480 (estimate)

storage temp. 

Refrigerator

solubility 

Soluble in tris-hydrochloric acid.

form 

Powder, Crystals, and/or Chunks

pka

5.40±0.50(Predicted)

color 

Off-white to beige or yellow to yellow-greenish or grayish-green

Sensitive 

Air & Light Sensitive

Merck 

14,7994

BRN 

906983

Stability:

Stable. Incompatible with strong bases, strong oxidizing agents.

CAS DataBase Reference

1121-31-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Mercaptopyridine-n-oxide(1121-31-9)

EPA Substance Registry System

2-Pyridinethiol, 1-oxide (1121-31-9)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22-63-20/21/22

Safety Statements 

26-36-24/25-36/37-22

RIDADR 

2811

WGK Germany 

3

RTECS 

UT8999000

F 

8-10-13-23

TSCA 

Yes

HS Code 

29333990

MSDS

• Language:English Provider:1-Hydroxy-2(1H)-pyridinethione
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Pyridinethiol 1-oxide Usage And Synthesis

Chemical Properties

off-white powder

Uses

2-Mercaptopyridine N-oxide is used in ratiometric fluorescence imaging of intracellular zinc ions in mammalian cultures. It is used in the radical coupling of benzoyl derivatives of 2-deoxy-D-ribose, with heterocyclic bases to give C-nucleosides. It acts as a ligand and form coordination complexes with palladium chloride. It is a precursor to O-acyl thiohydroxamates. Further, it serves as an antifungal agent. In addition to this, it is used in the preparation of 1-oxa-2-oxo-3-thia-indolizinium chloride by reaction with carbonyl dichloride.

Uses

Precursor to O-acyl thiohydroxamates. Ligates to metals to form biologically active complexes.

Definition

ChEBI: Pyrithione is a pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent. It has a role as an ionophore. It is a pyridinethione and a monohydroxypyridine. It is a tautomer of a pyridine-2-thiol N-oxide.

General Description

2-Mercaptopyridine N-oxide forms complexes on reaction with palladium chloride. It inhibits NADH-fumarate reductase purified from Trypanosoma cruzi. It is precursor to O-acyl thiohydroxamates. It ligates to metals to form biologically active complexes.

2-Pyridinethiol 1-oxide(1121-31-9)Related Product Information

• Sodium thioglycolate
• Magnesium oxide
• NICOTINIC ACID HYDRAZIDE
• Mercaptoacetic acid
• Calcium thioglycolate
• 2-Mercaptoethanol
• Propylene oxide
• Zinc oxide
• Cuprous oxide
• CHLOROPHOSPHONAZO III
• ETHYLENE OXIDE
• Pyridine-N-oxide
• Iron oxide
• 2-Ethylhexyl mercaptoacetate
• POTASSIUM THIOGLYCOLATE
• NITRIC OXIDE
• 2-Pyridinethione
• 3-Mercaptopropionic acid