Basic information Safety Supplier Related

2,2'-Furoin

Basic information Safety Supplier Related

2,2'-Furoin Basic information

Product Name:
2,2'-Furoin
Synonyms:
  • 1,2-Di(2-furyl)-2-hydroxyethanone
  • 1,2-di-2-furanyl-2-hydroxy-ethanon
  • 1,2-di-2-furanyl-2-hydroxyethanone
  • 1,2-di-2-furyl-2-hydroxy-ethanon
  • Ethanone, 1,2-di-2-furyl-2-hydroxy-
  • furoylfurylcarbinol
  • Furoylfu-rylcarbinol
  • Ketone, 2-furyl alpha-hydroxyfurfuryl
CAS:
552-86-3
MF:
C10H8O4
MW:
192.17
EINECS:
209-024-8
Product Categories:
  • Bioactive Small Molecules
  • Building Blocks
  • C8 to C11
  • Cell Biology
  • Chemical Synthesis
  • F
  • Pharmaceutical Intermediates
  • Building Blocks
  • Furans
  • Heterocyclic Building Blocks
  • Heterocyclic Building Blocks
Mol File:
552-86-3.mol
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2,2'-Furoin Chemical Properties

Melting point:
134-137 °C(lit.)
Boiling point:
248.14°C (rough estimate)
Density 
1.0825 (rough estimate)
refractive index 
1.4440 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
acetone: soluble0.25g/10 mL, clear, colorless to deep brown-yellow
form 
powder to crystal
pka
11.62±0.20(Predicted)
color 
White to Light yellow to Light orange
BRN 
383995
CAS DataBase Reference
552-86-3(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1,2-di-2-furanyl-2-hydroxy-(552-86-3)
EPA Substance Registry System
Ethanone, 1,2-di-2-furanyl-2-hydroxy- (552-86-3)
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Safety Information

WGK Germany 
3
RTECS 
KM5774095
TSCA 
Yes
HS Code 
29329990
Hazardous Substances Data
552-86-3(Hazardous Substances Data)

MSDS

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2,2'-Furoin Usage And Synthesis

Chemical Properties

LIGHT YELLOW TO LIGHT BROWN AMORPHOUS POWDER

Uses

Furoin was used as fluorogenic reagent for the selective and sensitive liquid chromatographic determination of various guanidines.

Preparation

2,2'-Furoin is prepared by the condensation of furfural with benzoin under the catalysis of potassium cyanide. 8L of water, 3L of ethanol, and 4kg of furfural were heated to 60-70°C on a water bath, and a solution of 200g potassium cyanide dissolved in 600Chemicalbookml of water was slowly added under stirring. The reaction exotherm automatically heated up to 80-90 ° C, and crystals were precipitated later. After standing, filter, wash the crystals with water and methanol until the washing is colorless, and recrystallize with ethanol, which is the finished product of bran coupler.

Purification Methods

It crystallises from MeOH (charcoal) and distils in a vacuum. [Hartman & Dickey J Am Chem Soc 55 1228 1933.] The (-)-enantiomer crystallises from toluene or EtOH with m 131-131o, and [] 20 -4.9o (dioxane) [Neuberg et al. Arch Biochem 1 393 1943, Beilstein 19 H 204, 19 I 710, 19 II 224, 19 III/IV 2543.]

2,2'-Furoin Preparation Products And Raw materials

Preparation Products

Raw materials

2,2'-FuroinSupplier

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